Can prophylactic argon plasma coagulation reduce delayed post-papillectomy bleeding? A prospective multicenter trial
- Abstract
- BACKGROUND AND AIM: Endoscopic post-papillectomy bleeding occurs in 3% to 20% of the cases, and delayed bleeding is also problematic. However, there is no consensus on how to reduce delayed post-papillectomy bleeding. The aim of this study was to evaluate the efficacy of prophylactic argon plasma coagulation (APC) to minimize delayed bleeding and reduce the persistence of residual tumors after endoscopic papillectomy. METHODS: In a prospective pilot study of patients with benign ampullary tumors, the prophylactic APC group underwent APC at the resection margin following a conventional snaring papillectomy. Then, 24h later after the papillectomy, all patients underwent a follow-up duodenoscopy to identify post-papillectomy bleeding and were followed up until 12months. The main outcomes were the delayed (≥24h) post-papillectomy bleeding rate and the tumor persistence rate. RESULTS: The delayed post-papillectomy bleeding rate was 30.8% (8/26) in the prophylactic APC group and 21.4% (6/28) in the non-APC group (P=0.434). The post-procedure pancreatitis rates were 23.1% (6/26) and 35.7% (10/28), respectively (P=0.310). The rate of tumor persistence did not differ between the two groups at 1month (12.5% vs 7.4%, P=0.656), 3months (4.2% vs 3.7%, P=1.00), 6months (8.3% vs 3.7%, P=0.595), and 12months (0% vs 3.7%, P=1.00). There were no procedure-related mortalities or serious complications. CONCLUSION: Prophylactic APC may not be effective in reducing delayed post-papillectomy bleeding or remnant tumor ablation immediately after conventional papillectomy (Clinical trial registration-cris.nih.go.kr; KCT0001955).
- All Author(s)
- J. K. Yang
; J. J. Hyun
; T. H. Lee
; J. H. Choi
; Y. N. Lee
; J. W. Choe
; J. S. Park
; C. I. Kwon
; S. Jeong
; H. J. Kim
; J. H. Moon
; S. H. Park
- Issued Date
- 2021
- Type
- Article
- Keyword
- Ampulla of Vater; Argon plasma coagulation; Bleeding; Papillectomy
- Publisher
- Asian Pacific Association of Gastroenterology
- ISSN
- 0815-9319
- Citation Title
- Journal of Gastroenterology and Hepatology
- Citation Volume
- 36
- Citation Number
- 2
- Citation Start Page
- 467
- Citation End Page
- 473
- Language(ISO)
- eng
- DOI
- 10.1111/jgh.15186
- URI
- http://schca-ir.schmc.ac.kr/handle/2022.oak/1074
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