Polymorphisms of ATF6B Are Potentially Associated With FEV1 Decline by Aspirin Provocation in Asthmatics
- Abstract
- Purpose: Endoplasmic reticulum (ER) stress has recently been observed to activate NF-kappaB and induce inflammatory responses such as asthma. Activating transcription factor 613 (ATF6B) is known to regulate ATFa-mediated ER stress response. The aim of this study is to investigate the associations of ATF6B genetic variants with aspirin-exacerbated respiratory disease (AERD) and its major phenotype, % decline of FEV1 by aspirin provocation. Methods: Four common single nucleotide polymorphisms (SNPs) of ATF6B were genotyped and statistically analyzed in 93 AERD patients and 96 aspirin-tolerant asthma (ATA) as controls. Results: Logistic analysis revealed that 2 SNPs (rs2228628 and rs8111, P=0.008; corrected P=0.03) and 1 haplotype (ATF6B-ht4, P=0.005; corrected P=0.02) were significantly associated with % decline of FEV1 by aspirin provocation, whereas ATF6B polymorphisms and haplotypes were not associated with the risk of AERD. Conclusions: Although further functional and replication studies are needed, our preliminary findings suggest that ATF6B may be related to obstructive phenotypes in response to aspirin exposure in adult asthmatics.
- All Author(s)
- T. J. Park
; J. H. Kim
; C. F. Pasaje
; B. L. Park
; J. S. Bae
; S. T. Uh
; Y. H. Kim
; M. K. Kim
; I. S. Choi
; B. W. Choi
; H. R. Shin
; J. S. Park
; I. Koh
; C. S. Park
; H. D. Shin
- Issued Date
- 2014
- Type
- Article
- Keyword
- ATF6B; aspirin exacerbated respiratory disease (AERD); single nucleotide polymorphism (SNP); haplotype
- Publisher
- 대한천식알레르기학회
대한소아알레르기호흡기학회
- ISSN
- 2092-7355
- Citation Title
- Allergy Asthma & Immunology Research
- Citation Volume
- 6
- Citation Number
- 2
- Citation Start Page
- 142
- Citation End Page
- 148
- Language(ISO)
- eng
- DOI
- 10.4168/aair.2014.6.2.142
- URI
- http://schca-ir.schmc.ac.kr/handle/2022.oak/1167
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