IL-4와 IFN-γ 유전자 다형성들의 아토피에 대한 상호 작용 모형
- Alternative Title
- An Interaction Model of IL-4 and IFN-γ Gene SNPs in Relation to Atopy
- Abstract
- Background: Asthma is a common complex genetic disease. While the T-helper cell 1 pathway is determined by cytokine interferon-gamma (IFN-γ), the T-helper cell 2 pathway is determined by IL-4. These comprise two alternative CD4+ T-cell fates with functional consequences for the host immune system. We investigated the effect of interaction between and IL-4 SNPs on asthma or atopy. Method: Three hundred asthmatics and 300 unrelated normal controls were enrolled. Two candidate SNPs of the IFN-γ gene and two SNPs of the IL-4 gene were selected. Gene-gene interactions were tested using the multi-factor dimensionality reduction (MDR) method and interaction information analysis on the basis of Shannon entropy. Result: In MDR analysis, a combination of IFN-γ+2459A>G and IL-4-589C>T was the best model to predict atopy. In interaction information analysis, there was a strong effect of interaction between theses two SNPs on atopy. This combination showed a stronger effect than each SNP alone. In addition, IL-4-589C>T showed a strong effect on atopy with IFN-γ+2671C>T and with IFN-γ+2459A>G. Theses effects were prominent in normal controls. Conclusion: From the findings of a statistical interaction model, it is suggested that IFN-γ and IL-4 gene SNPs may contributes to the development of atopy by interacting with each other.
- All Author(s)
- 이준혁
; 최종효
; 윤진아
; 박성우
; 김도진
; 장안수
; 박종숙
; 어수택
; 임태연
; 김용훈
; 신형두
; 박병래
; 박춘식
- Issued Date
- 2008
- Type
- Article
- Keyword
- Atopy; Epistasis; Polymorphism; IL-4; IFN-gamma
- Publisher
- 대한천식알레르기학회
- ISSN
- 1015-6372
; 1225-679x
; 1226-8739
- Citation Title
- 천식 및 알레르기
- Citation Volume
- 28
- Citation Number
- 1
- Citation Start Page
- 45
- Citation End Page
- 52
- Language(ISO)
- kor
- URI
- http://schca-ir.schmc.ac.kr/handle/2022.oak/1340
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