Low angiomotin-p130 with concomitant high Yes-associated protein 1 expression is associated with adverse prognosis of advanced gastric cancer
- Abstract
- Angiomotin (AMOT) promotes angiogenesis and plays a role in neovascularization during tumorigenesis. Recently, the AMOT isoform, AMOT-p130, was shown to exert a regulatory effect on Yes-associated protein 1 (YAP1), a major downstream effector of the Hippo pathway. The specific roles of AMOT-p130 and YAP1 in advanced gastric cancer (AGC) are yet to be established. In this study, a total of 166 patients with AGC were enrolled, and AMOT-p130 and YAP1 levels were analyzed by immunohistochemistry using tissue microarrays. Low AMOT-p130 together with high YAP1 expression (n = 30, 18.1%) was associated with high T stage (p = 0.042), high TNM stage (p = 0.025), and venous invasion (p = 0.048). A Kaplan-Meier survival analysis with log-rank test revealed a significant correlation with decreased AMOT-p130 coupled with high nuclear YAP1 expression with shorter overall survival (p = 0.0045) and disease-free survival (p = 0.0028). Furthermore, multivariate analyses showed that the low AMOT-p130/high YAP1 expression profile was an independent prognostic factor for disease-free survival (p = 0.008, HR = 1.874, CI, 1.177-2.986) and overall survival (p = 0.012, HR = 1.903, CI, 1.152-3.143). Our findings collectively demonstrate that low AMOT-p130 combined with high YAP1 expression is correlated with an unfavorable AGC prognosis.
- All Author(s)
- S. A. Hong
; M. W. Son
; J. Cho
; S. H. Jang
; H. J. Lee
; J. H. Lee
; H. D. Cho
; M. H. Oh
; M. S. Lee
- Issued Date
- 2017
- Type
- Article
- Keyword
- Advanced gastric cancer; angiomotin; Yes-associated protein 1; immunohistochemistry
- ISSN
- 0903-4641
- Citation Title
- Journal of Pathology, Microbiology and Immunology
- Citation Volume
- 125
- Citation Number
- 11
- Citation Start Page
- 996
- Citation End Page
- 1006
- Language(ISO)
- eng
- DOI
- 10.1111/apm.12750
- URI
- http://schca-ir.schmc.ac.kr/handle/2022.oak/1463
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