The incidence of venous thromboembolism is not lowin Korean patients with advanced pancreatic cancer
- Abstract
- BACKGROUND: Pancreatic cancer is among the most common malignancies associated with venous thromboembolism (VTE). Asian patients are known to have a lower incidence of VTE compared to Caucasian patients. However, few studies have investigated the incidence of VTE in Asian patients with pancreatic cancer. METHODS: This retrospective review of medical records was performed on 505 patients with histopathologically proven advanced stage pancreatic cancer, from January 2006 to December 2012, at Soonchunhyang University Hospitals. RESULTS: Ninety-four patients (18.6%) had at least one pulmonary embolism (PE), deep vein thrombosis (DVT), or splanchnic vein thrombosis (SVT); 38 patients had isolated SVT; and 56 patients (11.1%) had at least one classic VTE (PE and/or DVT of lower extremities). Patients with more advanced stages of pancreatic cancer (distant metastatic stage, recurrence) or who had received chemotherapy had a higher incidence of classic VTE. Patients who were simultaneously diagnosed with pancreatic cancer and classic VTE had a poorer prognosis than patients with subsequent VTEs. There was a significant difference in overall survival (OS) between the presence and absence of a concurrent classic VTE diagnosis (median: OS, 2.1 mo vs. 10.7 mo; P<0.001). Even when VTE included SVT, the result was similar (P<0.001). CONCLUSION: In Korean patients with advanced pancreatic cancer, the incidence of VTEs is comparable to that of Caucasian patients. We also found that pancreatic cancer patients with concurrent VTEs had a poor prognosis compared to patients who developed VTEs later.
- All Author(s)
- S. Y. Yoon
; M. Y. Lee
; J. Yun
; J. Yoon
; H. J. Kim
; K. H. Kim
; S. H. Kim
; S. C. Lee
; S. B. Bae
; C. K. Kim
; N. Lee
; N. S. Lee
; K. T. Lee
; S. K. Park
; D. S. Hong
; J. H. Won
- Issued Date
- 2018
- Type
- Article
- Keyword
- Korean; Advanced pancreatic cancer; Venous thromboembolism
- Publisher
- 대한혈액학회
- ISSN
- 2287-979X
; 2288-0011
- Citation Title
- Blood Research
- Citation Volume
- 53
- Citation Number
- 3
- Citation Start Page
- 227
- Citation End Page
- 232
- Language(ISO)
- eng
- DOI
- 10.5045/br.2018.53.3.227
- URI
- http://schca-ir.schmc.ac.kr/handle/2022.oak/1568
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