Phase II Clinical Trial of Genexol® (Paclitaxel) and Carboplatin for Patients with Advanced Non-small Cell Lung Cancer
- Abstract
- PURPOSE: This phase II clinical trial was conducted to evaluate the activity and safety of a combination treatment of paclitaxel (Genexol®) plus carboplatin in patients with advanced non-small cell lung cancer. MATERIALS AND METHODS: Chemotherapy-naïve patients having histologically confirmed advanced or metastatic non-small cell lung cancer were enrolled. Genexol® was administered at 225 mg/m(2) intravenous (IV) infusion over 3 hours, followed by carboplatin (area under the concentration-time curve=6) IV on day 1 every 3 weeks. RESULTS: Twenty-eight patients were enrolled between January 2003 and January 2005. A total of 110 cycles of chemotherapy were given. The median number of chemotherapy cycles was 4. A total of 25 study patients were evaluable. On an intent-to-treat basis, there were ten partial responses (response rate 35.7%). The median time-to-progression was 3.2 months (95% confidence interval [CI], 1.5 to 4.9) and the median overall survival was 8.2 months (95% CI, 4.1 to 12.3). The main hematologic grade 3/4 toxicity was neutropenia, which was observed in 14 (50.0%) patients. The main non-hematologic toxicity was peripheral neuropathy, which was observed in 12 patients (42.9%). Grade 3/4 neuropathy occurred in 8 patients (28.6%) and three patients discontinued treatment because of neuropathy. CONCLUSION: In this trial, the combination of Genexol® and carboplatin showed significant activity as first line treatment for patients with advanced or metastatic non-small cell lung cancer. However, a modest dose reduction of Genexol® is needed due to sensory neuropathy.
- All Author(s)
- H. J. Kim
; K. H. Kim
; J. Yun
; S. H. Kim
; S. C. Lee
; S. B. Bae
; C. K. Kim
; N. S. Lee
; K. T. Lee
; D. J. Kim
; S. K. Park
; J. H. Won
; D. S. Hong
; H. S. Park
- Issued Date
- 2011
- Type
- Article
- Keyword
- Non-small-cell lung carcinoma; Chemotherapy; Carboplatin; Genexol®
- Publisher
- 대한암학회
- ISSN
- 1598-2998
- Citation Title
- Cancer Research and Treatment
- Citation Volume
- 43
- Citation Number
- 1
- Citation Start Page
- 19
- Citation End Page
- 23
- Language(ISO)
- eng
- DOI
- 10.4143/crt.2011.43.1.19
- URI
- http://schca-ir.schmc.ac.kr/handle/2022.oak/1718
- 공개 및 라이선스
-
- 파일 목록
-
Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.