The impact of hyperuricemia on in-hospital mortality and incidence of acute kidney injury in patients undergoing percutaneous coronary intervention
- Abstract
- BACKGROUND: There is very little information about the relationship between hyperuricemia, acute kidney injury (AKI) and in-hospital mortality. METHODS AND RESULTS: With a retrospective analysis of the medical records, 1,247 patients who had percutaneous coronary intervention (PCI) were investigated. AKI was defined as an increase in serum creatinine of ≥0.5mg/dl or ≥50% over baseline within 7 days of PCI. The association of AKI with clinical, biochemical and procedural variables were examined. In addition, the association of hyperuricemia with in-hospital mortality was also examined. Of the 1,247 patients in the study population, 51 (4.1%) experienced AKI after PCI, 15 of whom required hemodialysis. In-hospital mortality occurred in 1.6% (20 of 1,247) in 19.6% (10 of 51) of AKI individuals, and 0.8% (10 of 1,186) of the non-AKI participants (odd ratios, 28.927; 95% confidence intervals, 11.411-73.328; P<0.001). In our study, the most powerful predictors of these variables were acute myocardial infarction, baseline estimated glomerular filtration rate (eGFR) <60 ml·min(-1)·1.73 m(-2), diabetics mellitus, anemia and hyperuricemia. Notably, the incidence of AKI after PCI markedly increased in diabetic or hyperuricemic patients with a baseline eGFR of <60 ml·min(-1)·1.73 m(-2). CONCLUSIONS: It is clear that AKI develops due to multiple risk factors. Our results indicate that hyperuricemia is independently associated with an increased risk of in-hospital mortality and AKI in patients treated with PCI.
- All Author(s)
- S. H. Park
; W. Y. Shin
; E. Y. Lee
; H. W. Gil
; S. W. Lee
; S. J. Lee
; D. K. Jin
; S. Y. Hong
- Issued Date
- 2011
- Type
- Article
- Keyword
- Ischemic heart disease; Kidney; Percutaneous coronary intervention; Renal failure
- Publisher
- Japanese Circulation Society
- ISSN
- 1346-9843
- Citation Title
- Circulation Journal
- Citation Volume
- 75
- Citation Number
- 3
- Citation Start Page
- 692
- Citation End Page
- 697
- Language(ISO)
- eng
- DOI
- 10.1253/circj.CJ-10-0631
- URI
- http://schca-ir.schmc.ac.kr/handle/2022.oak/1755
- 공개 및 라이선스
-
- 파일 목록
-
Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.