TET2 Mutation and High miR-22 Expression as Biomarkers to Predict Clinical Outcome in Myelodysplastic Syndrome Patients Treated with Hypomethylating Therapy
- Abstract
- Tet methylcytosine dioxygenase 2 (TET2) is one of the most frequently mutated genes in myelodysplastic syndrome (MDS). TET2 is known to involve a demethylation process, and the loss of TET2 is thought to cause DNA hypermethylation. Loss of TET2 function is known to be caused by genetic mutations and miRNA, such as miR-22. We analyzed 41 MDS patients receiving hypomethylating therapy (HMT) to assess whether TET2 mutation status and miR-22 expression status were associated with their clinical characteristics and treatment outcomes. Responsiveness to HMT was not affected by both TET2 mutation (odds ratio (OR) 0.900, p = 0.909) and high miR-22 expression (OR 1.548, p = 0.631). There was a tendency for TET2 mutation to be associated with lower-risk disease based on IPSS (Gamma = -0.674, p = 0.073), lower leukemic transformation (OR 0.170, p = 0.040) and longer survival (Hazard ratio 0.354, p = 0.059). Although high miR-22 expression also showed a similar tendency, this tendency was weaker than that of TET2 mutation. In summary, the loss of TET2 function, including both TET2 mutation and high miR-22 expression, was not a good biomarker for predicting the response to HMT but may be associated with lower-risk disease based on IPSS, lower leukemic transformation and longer survival.
- All Author(s)
- J. Yun
; Y. S. Ji
; G. H. Jang
; S. H. Lim
; S. H. Kim
; C. K. Kim
; S. B. Bae
; J. H. Won
; S. K. Park
- Issued Date
- 2021
- Type
- Article
- Keyword
- TET2; miR-22; hypomethylating therapy; myelodysplastic syndrome (MDS); hypermethylation; cytogenetic abnormality
- ISSN
- 1467-3037
- Citation Title
- Current Issues Molecular Biology
- Citation Volume
- 43
- Citation Number
- 2
- Citation Start Page
- 917
- Citation End Page
- 931
- Language(ISO)
- eng
- DOI
- 10.3390/cimb43020065
- URI
- http://schca-ir.schmc.ac.kr/handle/2022.oak/1873
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