Differences in Psychopathology between Offspring of Parents with Bipolar I Disorder and Those with Bipolar II Disorder: A Cross-Sectional Study
- Abstract
- Objective
The aim of this study was to evaluate differences in psychopathology between offspring of parents with bipolar I disorder (BP-I) and those with bipolar II disorder (BP-II).
Methods
The sample included 201 offspring between 6 and 17 years of age who had at least one parent with BP-I or BP-II. The offspring were diagnostically evaluated using the Korean Kiddie-Schedule for Affective Disorders and Schizophrenia-Present and Lifetime Version. Psychopathology and Clinical characteristics were evaluated, including lifetime DSM-5 diagnoses, depression, and childhood trauma. Lifetime DSM-5 diagnoses were also compared between schoolchildren aged 6 to 11 years and adolescents aged 12 to 17 years.
Results
In lifetime DSM-5 diagnoses, offspring of parents with BP-I had significantly increased risk of developing MDD and BP-I than those with BP-II. Regarding clinical characteristics, ADHD rating scale and childhood trauma scale were significantly higher in offspring of parents with BP-I than that in those with BP-II.
Conclusion
The present study supports that BP-I may be etiologically distinct from BP-II by a possible genetic liability. Our findings indicate that additional research related to bipolar offspring is needed to enhance understanding of differences between BP-I and BP-II.
- All Author(s)
- H. A. Lee
; J. S. Kim
; Y. J. Lee
; N. H. Heo
; S. H. Shim
; Y. J. Kwon
- Issued Date
- 2018
- Type
- Article
- Keyword
- Bipolar I disorder; Bipolar II disorder; Offspring; Schoolchildren; Adolescent
- Publisher
- 대한신경정신의학회
Korean Neuropsychiatric Association
- ISSN
- 1738-3684
; 1976-3026
- Citation Title
- Psychiatry Investigation
- Citation Volume
- 15
- Citation Number
- 12
- Citation Start Page
- 1135
- Citation End Page
- 1143
- Language(ISO)
- eng
- DOI
- 10.30773/pi.2018.10.22.1
- URI
- http://schca-ir.schmc.ac.kr/handle/2022.oak/2054
- 공개 및 라이선스
-
- 파일 목록
-
Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.