Fatigue is associated with depression independent of excessive daytime sleepiness in the general population
- Abstract
- PURPOSE: This study aimed to investigate sleep problems and comorbid conditions associated with fatigue in the general population. METHODS: The data were obtained from a nationwide cross-sectional survey conducted in 2018. The Fatigue Severity Scale was used to assess fatigue. We examined sleep habits, such as workday sleep duration, chronotype, and free-day catch-up sleep, excessive daytime sleepiness (EDS), depression, and other comorbid conditions. We conducted multiple logistic regression analysis with the presence of fatigue as a dependent variable. RESULTS: Of 2,493 adults aged 19 to 92 years, 50% men, mean age was 47.9± 16.4 years.The average workday sleep duration was 7.1 ± 1.1h, and the prevalence of fatigue was 31%. After adjusting for potential confounders, fatigue was associated with EDS (odds ratio [OR] 3.751, 95% confidence interval [CI] 2.928-4.805), depression (OR 3.736, 95% CI 2.701-5.169), perceived insufficient sleep (OR 1.516, 95% CI 1.249-1.839), free-day catch-up sleep (OR 1.123, 95% CI 1.020-1.235), less alcohol intake (OR 0.570, 95% CI 0.432-0.752), and physical inactivity (OR 0.737, 95% CI 0.573-0.948). On subgroup analysis, fatigue was additionally associated with short workday sleep duration (OR 0.899, 95% CI 0.810-0.997) in individuals without EDS. However, among those with EDS, only depression (OR 2.842, 95% CI 1.511-5.343) and less alcohol intake (OR 0.476, 95% CI 0.247-0.915) were associated with fatigue. CONCLUSION: Fatigue was significantly associated with depression independent of EDS. Further research is warranted to better understand the pathophysiological relationship between fatigue, depression, and sleep.
- All Author(s)
- J. S. Sunwoo
; D. Kim
; M. K. Chu
; C. H. Yun
; K. I. Yang
- Issued Date
- 2022
- Type
- Article
- Keyword
- Depression; Fatigue; Sleep duration; Sleepiness
- Publisher
- American Sleep Apnea Association
Sleep Disorders Dental Society
- ISSN
- 1520-9512
; 1522-1709
- Citation Title
- Sleep & breathing
- Citation Volume
- 26
- Citation Number
- 2
- Citation Start Page
- 933
- Citation End Page
- 940
- Language(ISO)
- eng
- DOI
- 10.1007/s11325-021-02448-3
- URI
- http://schca-ir.schmc.ac.kr/handle/2022.oak/2146
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