A comparison study on efficacy, insulin sensitivity and safety of Glimepiride/Metformin fixed dose combination versus glimepiride single therapy on type 2 diabetes mellitus patients with basal insulin therapy
- Abstract
- AIM: The aim of this study was to analyze the efficacy, insulin sensitivity and safety in the event of administering sulfonylurea-based drugs and metformin in combination with basal insulin. METHODS: A randomized, open-label, parallel, 16-week trial was conducted across four study centers. The 97 type 2 diabetic patients were selected and randomized into two groups, the insulin glargine plus fixed-dose combination glimepiride 1 mg and metformin 500 mg twice daily group (the G/M group) and the insulin glargine plus glimepiride 4 mg once daily group (the G group). The primary endpoint evaluated was change in HbA1c. The secondary endpoints evaluated were changes in fasting blood glucose (FPG), 2-h post prandial glucose (PPG 2 h), insulin, and C-peptide levels. RESULTS: The G/M group was found to have experienced a significantly greater decrease in HbA1c, as well as PPG 2 h compared to the G group. While no significant intergroup difference was found regarding FPG in the ITT, the G/M group in the PP set experienced a significantly greater decrease in FPG. CONCLUSION: Comparison of combined therapy consisting of either the G/M group or the G group indicated that both forms of therapy are relatively safe but that the former more effectively decreases blood glucose levels.
- All Author(s)
- H. M. Yu
; S. J. Kim
; S. W. Chun
; K. Y. Park
; D. M. Lim
; J. M. Lee
; J. H. Hong
; K. S. Park
- Issued Date
- 2019
- Type
- Article
- Keyword
- Type 2 diabetes mellitus; Sulfonylurea compounds; Metformin
- Publisher
- International Diabetes Federation
Western Pacific Region of IDF
- ISSN
- 0168-8227
- Citation Title
- Diabetes Research and Clinical Practice
- Citation Volume
- 155
- Citation Start Page
- 107796
- Citation End Page
- 107796
- Language(ISO)
- eng
- DOI
- 10.1016/j.diabres.2019.107796
- URI
- http://schca-ir.schmc.ac.kr/handle/2022.oak/2263
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