Optimal duration of proton pump inhibitor in the treatment of endoscopic submucosal dissection-induced ulcers: a retrospective analysis and prospective validation study
- Abstract
- BACKGROUND: The optimal duration of proton pump inhibitor (PPI) use in the treatment of endoscopic submucosal dissection (ESD)-induced ulcers has not been well defined. AIMS: The aim of study was to determine the optimal duration of PPI treatment for ESD-induced gastric ulcers. METHODS: A total of 333 patients who underwent ESD were included in this retrospective analysis and prospective randomized validation. Medical records and endoscopic images for the 221 patients in our ESD-database were reviewed retrospectively. Based on the results of the retrospective analysis, 112 patients with ESD-induced ulcers over 40 mm were randomly assigned to two groups (4- or 8-week course of Lansoprazole 30 mg). Main outcome measurements were to assess the healing-related factors of post-ESD ulcers (retrospective analysis) and to compare complete mucosal healing rate in large (≥ 40 mm) ESD-induced ulcers according to the duration of PPI treatment (prospective validation). RESULTS: Multivariate logistic regression from a retrospective analysis showed that a duration of PPI treatment <8 weeks and a post-ESD ulcer ≥ 40 mm in size were associated with incomplete healing. In a prospective validation, the rate of complete healing in the 8-week PPI group was significantly higher than that of the 4-week PPI group for a large (≥ 40 mm) ESD-induced ulcer at 8 weeks follow-up (83.3 vs. 42.6%, P < 0.01). CONCLUSIONS: The optimal duration of PPI treatment varies based on the initial ulcer size. Patients with an ESD-induced ulcer over 40 mm should be treated with an 8-week course of PPIs.
- All Author(s)
- S. H. Lee
; C. K. Lee
; I. K. Chung
; Y. S. Shim
; T. H. Lee
; H. S. Kim
; S. H. Park
; S. J. Kim
- Issued Date
- 2012
- Type
- Article
- Keyword
- Endoscopic submucosal dissection; Stomach; Ulcer; Proton pump inhibitors
- ISSN
- 0163-2116
- Citation Title
- Digestive Diseases and Sciences
- Citation Volume
- 57
- Citation Number
- 2
- Citation Start Page
- 429
- Citation End Page
- 434
- Language(ISO)
- eng
- DOI
- 10.1007/s10620-011-1941-2
- URI
- http://schca-ir.schmc.ac.kr/handle/2022.oak/2289
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