Papillary Thyroid Carcinoma Manifesting as an Autonomously Functioning Thyroid Nodule
- Abstract
- Hyperfunctioning thyroid carcinoma is very rare. Hence, radionuclide imaging of thyroid hot nodules usually suggests a benign tumor, and less than 4% of cases have been reported as malignant. We would like to present a case of a hyperfunctioning papillary thyroid carcinoma that was initially treated with radioactive iodine. A 58-year-old woman was referred to our hospital for palpable thyroid nodule and a 5-kg weight loss within 6 months. Thyroid function test revealed thyrotoxicosis, and thyroid autoantibodies were absent. Tc-99m thyroid scintigraphy showed a 2 x 2 cm-sized hyperactive hot nodule at the left lobe. Despite radioactive iodine treatment with a dose of 10 mCi(131)I, thyroid function did not improve. Fine needle aspiration revealed papillary thyroid cancer. The patient underwent total thyroidectomy. Although clinical features and thyroid scans suggest a benign nodule, the possibility of malignancy should not be ruled out. Malignant thyroid hot nodules are rare; however, its possibility should be taken into account. Therefore, we suggest that ruling out malignancy by existing diagnostic guidelines can misdiagnose even a typical case with benign features. As thyroid nodule detection is getting sensitive and accurate, we present this case to discuss whether additional diagnostic approaches would be necessary for thyroid nodules.
- All Author(s)
- J. H. Kim
; G. J. Na
; K. W. Kim
; H. J. Ko
; S. W. Jeon
; Y. J. Kim
; S. J. Kim
; H. D. Jo
; C. J. Kim
- Issued Date
- 2012
- Type
- Article
- Keyword
- Thyroid nodule; Papillary thyroid cancer
- Publisher
- 대한내분비학회
- ISSN
- 2093-596X
- Citation Title
- Endocrinology and Metabolism
- Citation Volume
- 27
- Citation Number
- 1
- Citation Start Page
- 59
- Citation End Page
- 62
- Language(ISO)
- eng
- DOI
- 10.3803/EnM.2012.27.1.59
- URI
- http://schca-ir.schmc.ac.kr/handle/2022.oak/2335
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