A Case of Monoclonal Gammopathy Associated with Aplastic Anemia: Insights into the Etiology and Points to be Considered During Diagnosis

Abstract

Monoclonal gammopathy involves the presence of clonal immunoglobulins, fragments, or free light chains of immunoglobulin in the serum or urine, and is usually considered a sign of plasma cell or B cell malignancies. However, monoclonal gammopathy could also be benign. Here, we present a case of monoclonal gammopathy associated with aplastic anemia, the diagnostic steps, and possible etiologies. Evaluating the cause of monoclonal gammopathy in hypocellular bone marrow could be challenging due to the high proportion of plasma cell and rarity of the combination of these two conditions. Therefore, extensive diagnostic analysis and follow-up tests are necessary to conduct accurate diagnosis.