Ratio of angiopoietin-2 to angiopoietin-1 predicts mortality in acute lung injury induced by paraquat
- Abstract
- Background: To determine whether initial reactive oxygen species (ROS)-induced endothelial cell injury is involved in early death after paraquat intoxication and concentrations of angiopoietin-1 (Ang-1), angiopoietin-2 (Ang-2), and von Willebrand factor (VWF) reflecting endothelial cell injury, we investigated the initial endothelial cell injury marker involved in the pathogenesis of death within 5 days after paraquat ingestion.
Material/methods: Sixty patients with paraquat poisoning were prospectively enrolled. Plasma samples were collected at admission. Plasma concentrations of Ang-1, Ang-2, and VWF were measured by enzyme-linked immunosorbent assay. The patients were classified into 3 categories: survivors, early death (died within 5 days after ingestion), and late death (died more than 5 days after ingestion).
Results: The baseline concentration of Ang-2 and the Ang-2: Ang-1 ratio were significantly higher in patients who died (Ang-2 [pg/mL], 1012.75 ± 468.02 vs. 1986.07 ± 1675.37 [p=0.002]; Ang-2: Ang-1, 0.90 ± 0.49 vs. 2.16 ± 2.28 [p=0.002]). The Ang-2: Ang-1 ratio was significantly higher in the early death group (2.41 ± 2.54) than in the survivors (0.90 ± 0.49) and the late death group (1.33 ± 0.64). The Ang-2: Ang-1 ratio was significantly associated with early death (OR, 2.602; 95% CI, 1.106-6.117; p=0.028) after adjusting for plasma levels of paraquat, age, PCO2, and creatinine. VWF did not predict mortality.
Conclusions: Endothelial cell damage could be involved in the pathogenesis of early death following paraquat ingestion.
- All Author(s)
- J. S. Choi
; K. A. Kwak
; M. J. Park
; Y. H. Kim
; H. W. Gil
; H. Y. Song
; S. Y. Hong
- Issued Date
- 2013
- Type
- Article
- Keyword
- paraquat; acute lung injury; angiopoietin; endothelial cells
- Publisher
- International Scientific Information, Inc
- ISSN
- 1234-1010
; 1643-3750
- Citation Title
- Medical science monitor
- Citation Volume
- 19
- Citation Start Page
- 28
- Citation End Page
- 33
- Language(ISO)
- eng
- DOI
- 10.12659/msm.883730
- URI
- http://schca-ir.schmc.ac.kr/handle/2022.oak/2394
- 공개 및 라이선스
-
- 파일 목록
-
Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.