Nimodipine and Steroid Combination Therapy for Idiopathic Sudden Sensorineural Hearing Loss
- Abstract
- Objective: To evaluate the treatment outcomes of nimodipine and steroid combination therapy for idiopathic sudden sensorineural hearing loss (ISSNHL).
Study design: Retrospective case review.
Setting: Tertiary referral center.
Patients: Seventy-eight patients who were diagnosed with ISSNHL were divided into two group based on the treatment strategies used: steroid+nimodipine (SN, n = 36) and steroid only (SO, n = 42) groups. Based on the level of hearing loss before treatment, subgroup analysis (<90 dB HL, SN-S versus SO-S groups; ≥90 dB HL, SN-P versus SO-P groups) was performed.
Interventions: Nimodipine+dexamethasone versus dexamethasone alone.
Main outcome measures: Hearing thresholds and complete/partial recovery rate after treatment.
Results: Hearing thresholds after treatment were not significantly different between the SN and SO groups (46.8 ± 29.4 versus 54.8 ± 27.6 dB HL, p = 0.218). However, the complete recovery rate was significantly higher in the SN group than in the SO group (41.7% versus 16.8%, p = 0.014). In subgroup analysis, the complete recovery rate was significantly higher in the SN-S group than in the SO-S group (60.9% versus 19.2%, p = 0.003), whereas the difference between the SN-P and SO-P groups was not significant (7.7% versus 12.5%, p = 0.672). The cumulative incidence of complete recovery was significantly higher in SN-S group than in the SO-S group (p = 0.005); the mean recovery time was 4.4 weeks (95% confidence interval [CI], 2.8-6.1) in the SN-S group and 8.8 weeks (95% CI, 7.0-10.5) in the SO-S group.
Conclusions: The results of this study suggest that nimodipine and steroid combination therapy for ISSNHL results in a higher complete recovery rate than steroid alone in patients with moderate to severe hearing loss.
- All Author(s)
- J. J. Han
; J. Y. Jung
; K. H. Park
; H. Y. Lee
; B. D. Lee
; S. J. Choi
; C. K. Lee
- Issued Date
- 2020
- Type
- Article
- Keyword
- Hearing recovery; Nimodipine; Steroid; Sudden hearing loss
- Publisher
- American Otological Society
American Laryngological Rhinological and Otological Society
American Laryngological Association
- ISSN
- 0192-9763
; 1531-7129
; 1537-4505
- Citation Title
- Otology & neurotology
- Citation Volume
- 41
- Citation Number
- 7
- Citation Start Page
- e783
- Citation End Page
- e789
- Language(ISO)
- eng
- DOI
- 10.1097/mao.0000000000002695
- URI
- http://schca-ir.schmc.ac.kr/handle/2022.oak/2583
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