Clinical Features and Prognosis of Spontaneous Bacterial Peritonitis in Korean Patients with Liver Cirrhosis: A Multicenter Retrospective Study
- Abstract
- Background/Aims: Although early recognition and treatment with effective antibiotics have lead to improvements in the prognosis of patients with spontaneous bacterial peritonitis (SBP), it remains to be a serious complication in cirrhotic patients. This study was designed to evaluate the clinical manifestations and prognosis of patients with liver cirrhosis and SBP in Korea. Methods: This was a multicenter retrospective study examining 157 episodes of SBP in 145 patients with cirrhosis. SBP was diagnosed based on a polymorphonuclear cell count in ascitic fluid of >250 cells/mm(3) in the absence of data compatible with secondary peritonitis. Results: The mean age of the cohort was 56 years, and 121 (77%) of the 157 episodes of SBP occurred in men. Microorganisms were isolated in 66 episodes (42%): Gram-negative bacteria in 54 (81.8%), Gram-positive in 11 (16.7%), and Candida in 1. Isolated Gram-negative organisms were resistant to third-gene ration cephalosporin in 6 cases (17%), to ciprofloxacin in 11 (20.8%), and to penicillin in 33 (62.3%). The treatment failure and in-hospital mortality rates were 12.1% and 21%, respectively. A high Model of End-Stage Liver Disease (MELD) score, SBP caused by extended-spectrum beta-lactamase-producing organisms, and hepatocellular carcinoma were independent prognostic factors of high in-hospital mortality. Conclusions: SBP remains to be a serious complication with high in-hospital mortality, especially in patients with a high MELD score. (Gut and Liver 2009;3:197-204)
- All Author(s)
- J. Heo
; Y. S. Seo
; H. J. Yim
; T. Hahn
; S. H. Park
; S. H. Ahn
; J. Y. Park
; M. Y. Kim
; S. K. Park
; M. Cho
; S. H. Um
; K. H. Han
; H. S. Kim
; S. K. Baik
; B. I. Kim
; S. H. Cho
- Issued Date
- 2009
- Type
- Article
- Keyword
- Liver cirrhosis; Peritonitis; Prognosis; Resistance
- Publisher
- 대한소화기학회
- ISSN
- 1976-2283
- Citation Title
- Gut and Liver
- Citation Volume
- 3
- Citation Number
- 3
- Citation Start Page
- 197
- Citation End Page
- 204
- Language(ISO)
- eng
- DOI
- 10.5009/gnl.2009.3.3.197
- URI
- http://schca-ir.schmc.ac.kr/handle/2022.oak/2824
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