폐경 후 여성에서 저용량 성장 호르몬 요법이 골밀도, 인슐린양 성장인자, 악력 및 체지방과 혈중 지질 성분에 미치는 영향에 대한 연구

Abstract

OBJECTIVE: To determine the effect of low-dose growth hormone (GH) replacement therapy on bone mineral density at the lumbar spine and femur, IGF-1, hand grip, body fat and serum lipid compositions in postmenopausal women. METHODS: A total of 9 postmenopausal women were assigned to receive growth hormone with a daily dose 0.0095 IU/kg, six times a week. We compared the change of bone marrow density (BMD), bone marker (osteocalcin), IGF-1, hand grip strength, body fat and serum lipid compositions during therapy. Repeated measure ANOVA test was used for statistical analysis. RESULTS: The results were as follows. 1. Mean age of the patients was 62.2 +/- 2.7 years. 2. The bone marker, osteocalcin level at 3 and 6 months were increased by 28% and 35% respectively, compared to baseline (p<0.05). 3. Serum IGF-1 level at 1, 3 and 6 months were increased by 61%, 46% and 15% respectively, compared to baseline (p<0.05). 4. Lumbar and spine bone marrow density (BMD) were increased during GH treament, but not significant (p>0.05). 5. Hand grip strength at 6 months was increased by 7.8% compared to baseline (p<0.05). 6. The body fat composition at 6 months treament was showed a 0.75% decrease with no statistical significance (p>0.05). 7. The total cholesterol, triglyceride and LDL cholesterol were decreased during GH treament, but not significance (p>0.05). The HDL cholesterol was increased with no statistical significance (p>0.05). CONCLUSION: Our study results suggest that low-dose GH replacement therapy in postmenopausal women have beneficial effect on increased BMD, hand grip strength and HDL cholesterol. The present findings provide useful information regarding the use of low-dose GH treament in elderly women with osteoporosis.