3차원 생체모사체 제작의 최신지견
- Alternative Title
- Recent Advances in Three-Dimensional Multicellular Spheroid Formation for Biomedical Research
- Abstract
- Multicellular spheroids (MCSs) from three dimensional culture, which is a complex architectural structure with dynamic cell to cell and cell to matrix interactions, mimic real tissues regarding structural and functional properties. MCSs have emerged as an effective tool for filling up the gap between the in vitro and in vivo experimental model and can replace the in vivo model. The viability and functional performance can be enhanced when cells are grown as multicellular spheroid (MCS). In this review paper, we discussed the basic mechanism of MCS formation, their biomedical applications, and recent advances in MCS culture and tissue engineering.
- All Author(s)
- J. H. Park
- Issued Date
- 2020
- Type
- Article
- Keyword
- Multicellular spheroids; Cell culture techniques; Tissue engineering
- Publisher
- 대한이비인후과학회
Korean Society of Otorhinolaryngology-Head and Neck Surgery
- ISSN
- 2092-5859
; 2092-6529
- Citation Title
- Korean Journal of Otorhinolaryngology-Head and Neck Surgery
- Citation Volume
- 63
- Citation Number
- 6
- Citation Start Page
- 245
- Citation End Page
- 251
- Language(ISO)
- kor
- DOI
- 10.3342/kjorl-hns.2020.00465
- URI
- http://schca-ir.schmc.ac.kr/handle/2022.oak/2940
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