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Etiology, Characteristics, and Outcomes of Community-Onset Pyomyositis in Korea: A Multicenter Study

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Abstract
BACKGROUND: Pyomyositis (PM) is a serious soft tissue infection and despite its clinical importance, previous studies have not been able to fully determine the clinical characteristics and microbial epidemiology of PM in Korea, which we therefore aimed to investigate. MATERIALS AND METHODS: We retrospectively identified 140 adult patients diagnosed with PM from 13 general hospitals between January 2012 and December 2015. We analyzed the clinical and microbial characteristics of community-onset PM and compared them with community-acquired (CA) and healthcare-associated (HCA) PM. RESULTS: One hundred eleven organisms were isolated from 96 (68.6%) patients with PM. Staphylococcus aureus (38 patients) was the most common pathogen, followed by streptococci (24 patients), and enteric Gram-negative organisms (27 patients). Methicillin-resistant S. aureus (MRSA) was identified in four (2.9%) patients and in-hospital mortality reached 8.6% (12/140). Enterococci isolates were identified in the HCA PM subgroup only The proportion of MRSA isolates was not comparable between CA and HCA PM subgroups. In the 83 patients with PM infected by monomicrobial pathogens, isolates of Gram-negative organisms were more commonly found in HCA PM subgroup than in CA PM subgroup (47.6% [10/21] of patients with HCA PM vs. 20.7% [12/58] of patients with CA PM; P = 0.01). CONCLUSION: Gram-positive cocci such as S. aureus and streptococci were dominant etiologies in community-onset PM, whereas MRSA appears to an uncommon causative organism of PM in Korea. Enteric Gram-negative organisms should also be considered as major etiologies, especially in HCA PM patient population in Korea.
All Author(s)
T. Kim ; S. Y. Park ; Y. G. Kwak ; J. Jung ; M. C. Kim ; S. H. Choi ; S. N. Yu ; H. L. Hong ; Y. K. Kim ; E. H. Song ; K. H. Park ; O. H. Cho
Issued Date
2021
Type
Article
Keyword
CommunityEtiologyPyomyositis
Publisher
대한감염학회
ISSN
2093-2340 ; 1598-8112
Citation Title
Infection & Chemotherapy
Citation Volume
53
Citation Number
1
Citation Start Page
46
Citation End Page
52
Language(ISO)
eng
DOI
10.3947/ic.2020.0102
URI
http://schca-ir.schmc.ac.kr/handle/2022.oak/3024
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