Clinical Outcomes and Response Predictors of Vedolizumab Induction Treatment for Korean Patients With Inflammatory Bowel Diseases Who Failed Anti-TNF Therapy: A KASID Prospective Multicenter Cohort Study
- Abstract
- BACKGROUND: We investigated the real-life effectiveness and safety of vedolizumab (VDZ) induction therapy among Korean patients with Crohn disease (CD) or ulcerative colitis (UC) for whom anti-tumor necrosis factor therapy previously failed. METHODS: Adult patients who started VDZ induction therapy at 16 centers were prospectively enrolled in the Korean VDZ nationwide registry. The coprimary outcomes were clinical remission, defined as a Crohn's Disease Activity Index score <150 points and a partial Mayo score ≤2 points with a combined rectal bleeding and stool frequency subscore ≤1 point at week 14 and endoscopic remission defined as a Mayo endoscopic subscore ≤1 point. We also analyzed predictors of clinical remission. RESULTS: Between August 2017 and November 2019, a total of 158 patients (80 with CD and 78 with UC) received VDZ induction therapy. Clinical remission rates among patients with CD and patients with UC were 44.1% and 44.0%, respectively. Among patients with UC, the endoscopic remission rate was 32.4%. Clinical response and remission rates showed increasing trends during induction therapy. Multivariable analysis revealed that clinical response at week 6 was the only predictor of clinical remission at week 14 for both patients with CD and patients with UC. Among patients who experienced 1 or more adverse events (n = 71; 44.9%), disease exacerbation (n = 28; 17.7%) was the most common adverse event. CONCLUSIONS: Among Korean patients with CD or UC for whom anti-tumor necrosis factor therapy failed, VDZ induction therapy was effective and safe. The early clinical response was associated with clinical remission after VDZ induction therapy.
- All Author(s)
- J. Kim
; H. Yoon
; N. Kim
; K. M. Lee
; S. A. Jung
; C. H. Choi
; E. S. Kim
; Y. Jung
; C. S. Eun
; T. O. Kim
; S. B. Kang
; Y. S. Kim
; G. S. Seo
; C. K. Lee
; J. P. Im
; S. J. Park
; D. I. Park
; B. D. Ye
- Issued Date
- 2021
- Type
- Article
- Keyword
- vedolizumab; Crohn disease; ulcerative colitis; Korea
- Publisher
- Crohn's & Colitis Foundation of America
- ISSN
- 1078-0998
- Citation Title
- Inflammatory Bowel Diseases
- Citation Volume
- 27
- Citation Number
- 12
- Citation Start Page
- 1931
- Citation End Page
- 1941
- Language(ISO)
- eng
- DOI
- 10.1093/ibd/izaa361
- URI
- http://schca-ir.schmc.ac.kr/handle/2022.oak/3038
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