Association Between c-Met and Lymphangiogenic Factors in Patients With Colorectal Cancer
- Abstract
- PURPOSE: Animal models show a strong relationship between lymphangiogenesis and lymph node metastasis. However, the clinical significance of lymphangiogenesis in patients with colorectal cancer (CRC) remains uncertain. This study aimed to evaluate the association between c-Met and lymphangiogenic factors and to elucidate the prognostic significance of c-Met in patients with CRC. METHODS: A total of 379 tissue samples were obtained from surgically resected specimens from patients with CRC at Soonchunhyang University Cheonan Hospital between January 2002 and December 2010. The expressions of c-Met, vascular endothelial growth factor (VEGF)-C, VEGF-D, VEGF receptor (VEGFR)-3, and podoplanin were examined using immunohistochemistry. The expression of c-Met and clinical factors were analyzed. RESULTS: Of the 379 tissues, 301 (79.4%) had c-Met expression. High expression of c-Met in tumor cells was significantly associated with high expression of VEGF-C (P < 0.001) and VEGFR-3 (P = 0.001). However, no statistically significant association with podoplanin (P = 0.587) or VEGF-D (P = 0.096) was found. Of the 103 evaluable patients, expression of c-Met in tumor cells was significantly associated with advanced clinical stage (P = 0.020), positive lymph node status (P = 0.038), and high expression of VEGF-C (P = 0.020). However, no statistically significant association with podoplanin (P = 0.518), VEGFR-3 (P = 0.085), VEGF-D (P = 0.203), or overall survival (P = 0.360) was found. CONCLUSION: Our results provide indirect evidence for an association and possible regulatory link of c-Met with the lymphangiogenic markers, but c-Met expression in patients with CRC is not a prognostic indicator for overall survival.
- All Author(s)
- H. J. Kim
; M. J. Baek
; D. H. Kang
; S. C. Lee
; S. B. Bae
; K. T. Lee
; N. Lee
; H. Kim
; D. Jeong
; T. S. Ahn
; M. S. Lee
; D. S. Hong
; J. H. Won
- Issued Date
- 2018
- Type
- Article
- Keyword
- Colorectal neoplasms; Lymphangiogenesis; c-Met
- ISSN
- 2287-9714
; 2287-9722
- Citation Title
- Annals of Coloproctology
- Citation Volume
- 34
- Citation Number
- 2
- Citation Start Page
- 88
- Citation End Page
- 93
- Language(ISO)
- eng
- DOI
- 10.3393/ac.2017.10.10
- URI
- http://schca-ir.schmc.ac.kr//handle/2022.oak/311
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