후천성 멜라닌세포성 모반의 bcl-2와 PCNA발현에 관한 면역조직화학적 연구

Abstract

BACKGROUND: The histogenesis of acquired melanocytic nevi is still a matter of debate. One considers that nevus cells originate from epidermal melanocytes and the other postulates that nevus cells are of both neural and melanocytic origin. OBJECTIVE: To clarify this controversy, investigation of the growth dynamics and tissue homeostasis of nevi is needed. METHODS: We compared expressions for PCNA and bcl-2 in 12 intradermal nevi and 8 compound nevi by immunohistochemical staining. RESULTS: The results are summarizid as follows: 1. bcl-2 : Both intradermal and compound nevi exhibited strong perinuclear and cytoplasmic staining. There was diminution of staining with progressive descent into the dermis. 2. PCNA : The mean rate of PCNA-positive nevus cells was higher in compound nevi than in intradermal nevi. CONCLUSION: The findings of our study shows considerable differences between intradermal nevi and compound nevi in expressions for PCNA and bcl-2.