초음파로 진단된 비알코올 지방간 환자에서 Cytokeratin-18과 대사 지표와의 상관관계
- Alternative Title
- Clinical Correlation between Serum Cytokeratin-18 and Metabolic Parameters in Patients with Sonographic Non-alcoholic Fatty Liver Disease
- Abstract
- BACKGROUND/AIMS: The serum cytokeratin-18 (CK-18) has been suggested to be a surrogate marker of non-alcoholic fatty liver disease (NAFLD). The aim of this study was to investigate the correlation between CK-18 and metabolic parameter in NAFLD patients. Correlation between CK-18 and macronutrient composition was also assessed. METHODS: A total of 212 subjects were recruited. Blood chemistry including fasting glucose, cholesterol level, AST, ALT, and CK-18 were compared. Data on calorie intake and carbohydrate consumption were acquired by five-day-diet diary using 24 hour recall method. RESULTS: Plasma CK-18 were markedly increased in patient with NAFLD compared with control group (420.4+/-282.3 vs. 313.6+/-179, p<0.001). Plasma CK-18 were positively correlated with systolic blood pressure (r=0.130), ALT (r=0.503) and negatively correlated with HDL cholesterol (r=-0.246). NAFLD patients with metabolic syndrome had higher CK-18 level than those without metabolic syndrome (484.0 vs. 372.1 U/L, p=0.021). When NAFLD patients were subdivided into two groups with CK-18 cut-off value of 400 U/L, patients with CK-18 level over 400 U/L showed higher body mass index (28.0+/-4.5 vs. 25.5+/-4.3), subcutaneous abdominal fat (283.5+/-172.2 vs. 195.7+/-147.8), AST (52.7+/-26.3 vs. 40.7+/-23.5) and ALT (102.0+/-52.6 vs. 61.2+/-32.2). Calorie intake (r=0.301) and carbohydrate intake (r=0.305) also showed positive correlation with CK-18. CONCLUSIONS: Plasma CK-18 showed positive correlation with metabolic parameters as well as calorie and carbohydrate intake when its cut-off value of greater than 400 U/L was used.
- All Author(s)
- D. S. Kwak
; D. W. Jun
; Y. K. Cho
; S. M. Lee
; S. H. Lee
; I. S. Jung
; S. W. Lee
; J. K. Park
; J. Lee
; E. Y. Lee
; M. Rho
; K. L. Lee
; J. K. Ko
; S. E. Park
- Issued Date
- 2014
- Type
- Article
- Keyword
- Non-alcoholic fatty liver disease; Keratin-18; Metabolic syndrome; Carbohydrates
- Publisher
- 대한소화기학회
The Korean Society of Gastroenterology
- ISSN
- 1598-9992
; 2233-6869
- Citation Title
- 대한소화기학회지
The Korean Journal of Gastroenterology
- Citation Volume
- 64
- Citation Number
- 4
- Citation Start Page
- 206
- Citation End Page
- 212
- Language(ISO)
- kor
- DOI
- 10.4166/kjg.2014.64.4.206
- URI
- http://schca-ir.schmc.ac.kr/handle/2022.oak/3163
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