특발성 혈소판 감소성 자반증 환자의 초치료로서 고용량 덱사메타손 요법
- Alternative Title
- Initial Therapy with High-Dose Dexamethasone for Patients with Idiopathic Thrombocytopenic Purpura
- Abstract
- Background: Corticosteroids have been widely used for treatingidiopathic thrombocytopenic purpura (ITP) as a first-line treatment. Several different pulsed high-dose dexamethasone therapies for adult ITP have been reported on. We assessed the effectiveness of a single course of high dose dexamethasone as first-line treatment for adult patients with ITP.
Methods: The subjects of the study were previously untreated adult patients with newly diagnosed ITP and who had a platelet count of less than 20,000/ՌL or a platelet count less than 50,000/ՌL. High-dose dexamethasone at a dose of 40mg/day for four consecutive days was given orally. A response was defined as an increase in the platelet count of at least 30,000/ՌL and a platelet count of more than 50,000/ՌL by day 10 after the initial treatment. A sustained response was defined as a platelet count of more than 50,000/ՌL that was maintained for six months after the initial treatment.
Results: Twenty two patients were eligible. The median platelet count before treatment was 19,000/ՌL. Seventeen patients (77%) among the 22 patients achieved an initial response by day 10: the mean platelet count 10 days after the initial treatment was 144,000/ՌL (range: 51,000 to 428,000/ՌL). Among the patients with a response, 4 (23.5%) had a sustained response, and the other 13 (76.5%) relapsed within six months. All the patients well tolerated the high-dose dexamethasone treatment.
Conclusion: A single course of high-dose dexamethasone is effective as an initial treatment for adults ITP patients, although the response duration is short. To maintain the response, repeated high-dose dexamethasone treatment may be needed or other alternative therapies can be considered.
- All Author(s)
- J. A. Yoon
; C. K. Kim
; S. H. Kim
; K. H. Kim
; H. J. Kim
; S. K. Park
; S. C. Lee
; N. S. Lee
; S. B. Bae
; K. T. Lee
; J. H. Won
; H. S. Park
; D. S. Hong
- Issued Date
- 2009
- Type
- Article
- Keyword
- Idiopathic thrombocytopenic purpura (ITP); Dexamethasone; Treatment
- Publisher
- 대한혈액학회
대한조혈모세포이식학회
대한혈전지혈학회
대한소아혈액종양학회
the Koreans Society of Hematology
the Korean Society of Blood and Marrow Transplantation
the Korean Society on Thrombosis and Hemostasis
the Korean Society of Pediatric Hematolog-Oncology
- ISSN
- 1738-7949
; 2092-9129
- Citation Title
- The Korean journal of hematology
- Citation Volume
- 44
- Citation Number
- 1
- Citation Start Page
- 22
- Citation End Page
- 27
- Language(ISO)
- kor
- DOI
- 10.5045/kjh.2009.44.1.22
- URI
- http://schca-ir.schmc.ac.kr/handle/2022.oak/3214
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