Clinical outcomes of patients with a single hepatocellular carcinoma less than 5 cm treated with transarterial chemoembolization
- Abstract
- Background/Aims
Transarterial chemoembolization (TACE) is performed for single hepatocellular carcinoma (HCC) that are not eligible for surgery or ablation therapy. We investigated the clinical outcomes of patients with a single HCC ≤ 5 cm treated with TACE.
Methods
This study analyzed 175 consecutive patients who underwent TACE as an initial treatment for single HCC ≤ 5 cm. Predictive factors for complete response (CR), recurrence after CR, and overall survival (OS) were evaluated.
Results
Total 119 patients (68%) achieved CR after TACE. Tumor size < 3 cm and hepatitis B virus infection were significant predictors of CR (p < 0.05). Recurrent HCC was detected in 73 patients (61.3%) after CR. Age > 65 years and absence of liver cirrhosis were predictive factors for non-recurrence after CR (p < 0.05). The OS for all patients was 80.7 ± 5.6 months, and the 1-, 3-, and 5-year OS rates were 88.1%, 64.8%, and 49.9%, respectively. In multivariate analysis for OS, CR (hazard ratio [HR], 0.467; 95% confidence interval [CI], 0.292 to 0.747) and Child class A (HR, 0.390; 95% CI, 0.243 to 0.626) were significant factors. The OS for the CR and Child class A group were 92 and 93.6 months, respectively, and that of the non-CR and Child B, C group were 53.3 and 50.7 months, respectively (p < 0.001).
Conclusions
TACE can be a valid treatment in patients with a single HCC ≤ 5 cm not suitable for curative treatment, especially in patients with Child class A and CR after TACE.
- All Author(s)
- M. Y. Baek
; J. J. Yoo
; S. W. Jeong
; J. Y. Jang
; Y. K. Kim
; S. O. Jeong
; S. H. Lee
; S. G. Kim
; S. W. Cha
; Y. S. Kim
; Y. D. Cho
; H. S. Kim
; B. S. Kim
; Y. J. Kim
; S. Y. Park
- Issued Date
- 2019
- Type
- Article
- Keyword
- Carcinoma, hepatocellular; Chemoembolization, therapeutic; Survival
- Publisher
- 대한내과학회
Korean Association of Internal Medicine
- ISSN
- 1226-3303
; 2005-6648
- Citation Title
- The Korean journal of internal medicine
- Citation Volume
- 34
- Citation Number
- 6
- Citation Start Page
- 1223
- Citation End Page
- 1232
- Language(ISO)
- eng
- DOI
- 10.3904/kjim.2018.058
- URI
- http://schca-ir.schmc.ac.kr/handle/2022.oak/3223
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