The dose of cyclophosphamide for treating paraquat-induced rat lung injury
- Abstract
- Background/Aims
Cyclophosphamide (CP) is a promising treatment for severe cases of paraquat (PQ) poisoning. We investigated the effective dose of CP for mitigating PQ-induced lung injury.
Methods
Adult male Sprague-Dawley rats were allocated into five groups: control, PQ (35 mg/kg, intraperitoneal injection), and PQ + CP (1.5, 15, or 30 mg/kg). The dimensions of lung lesions were determined using X-ray microtomography (micro-CT), and histological changes and cytokine levels were recorded.
Results
The micro-CT results showed that 15 mg/kg CP was more effective than 1.5 mg/kg CP for treating PQ-induced lung injury. At a dose of 1.5 mg/kg, CP alleviated the histological evidence of inflammation and altered superoxide dismutase activity. Using 15 mg/kg CP reduced the elevated catalase activity and serum transforming growth factor (TGF)-β1 level.
Conclusions
A CP dose of > 15 mg/kg is effective for reducing the severity of PQ-induced lung injury as determined by histological and micro-CT tissue examination, possibly by modulating antioxidant enzyme and TGF-β1 levels.
- All Author(s)
- J. S. Choi
; S. S. Jou
; M. H. Oh
; Y. H. Kim
; M. J. Park
; H. W. Gil
; H. Y. Song
; S. Y. Hong
- Issued Date
- 2013
- Type
- Article
- Keyword
- Paraquat; Cyclophosphamide; Reactive oxygen species; X-ray microtomography
- Publisher
- 대한내과학회
Korean Association of Internal Medicine
- ISSN
- 1226-3303
; 2005-6648
- Citation Title
- The Korean journal of internal medicine
- Citation Volume
- 28
- Citation Number
- 4
- Citation Start Page
- 420
- Citation End Page
- 427
- Language(ISO)
- eng
- DOI
- 10.3904/kjim.2013.28.4.420
- URI
- http://schca-ir.schmc.ac.kr/handle/2022.oak/3232
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