Immunohistochemical expression of COX-2 in thyroid nodules
- Abstract
- Background:
Recent evidence indicates that elevated COX-2 expression is associated with the carcinogenesis of numerous neoplasms. In this study, we investigated COX-2 expression in various thyroid specimens in order to elucidate its physiological role in pathologic conditions, and to evaluate the efficiency of COX-2 protein expression as a molecular marker of malignancy in the thyroid gland.
Methods:
COX-2 expression was studied immunohistochemically in 19 papillary carcinomas, 8 follicular carcinomas, 14 follicular adenomas, 2 Hürthle cell carcinomas, 4 Hürthle cell adenomas, 8 nodular hyperplasias, 3 Graves’ diseases, 3 Hashimoto’s thyroiditis, 2 medullary carcinomas, 1 anaplastic carcinoma, and 20 normal thyroid tissues.
Results:
COX-2 staining was not seen in any of the normal thyroid, Graves’ disease, or nodular hyperplasia specimens. In contrast, COX-2 staining was observed in all of papillary carcinomas, Hashimoto’s thyroiditis, Hürthle cell carcinomas, and Hürthle cell adenomas tissues. Moreover, 7 of 8 follicular carcinomas and 11 of 14 follicular adenomas showed COX-2 staining.
Conclusion:
These results indicate that COX-2 is not useful as a marker of malignancy. Since COX-2 expression was evident in follicular adenomas and in papillary and follicular carcinomas. Thus, the enzyme may be involved in the early process of thyroid tumorigenesis.
- All Author(s)
- S. J. Kim
; J. H. Lee
; J. S. Yoon
; J. O. Mok
; Y. J. Kim
; H. K. Park
; C. H. Kim
; D. W. Byun
; K. I. Suh
; M. H. Yoo
- Issued Date
- 2003
- Type
- Article
- Keyword
- COX-2; Thyroid nodule; Immunohistochemistry
- Publisher
- 대한내과학회
Korean Association of Internal Medicine
- ISSN
- 1226-3303
; 2005-6648
- Citation Title
- The Korean journal of internal medicine
- Citation Volume
- 18
- Citation Number
- 4
- Citation Start Page
- 225
- Citation End Page
- 229
- Language(ISO)
- eng
- DOI
- 10.3904/kjim.2003.18.4.225
- URI
- http://schca-ir.schmc.ac.kr/handle/2022.oak/3246
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