Increased expression of cyclooxygenase-2 is associated with the progression to cirrhosis
- Abstract
- Background/Aims
To investigate the degree of cyclooxygenase-2 (COX-2) protein expression in chronic hepatitis and cirrhosis.
Methods
COX-2 protein expression was evaluated in 43 cases of chronic hepatitis and 24 cases of cirrhosis using immunohistochemical techniques. The COX-2 immunohistochemical staining score was assessed using the scoring systems of Pazirandeh et al and Qiu et al. and each scoring system was based on a sum of the parameters of staining intensity and distribution.
Results
The mean COX-2 expression scores in chronic hepatitis and cirrhosis were 2.5 ± 1.3 vs. 3.3 ± 1.1 (p = 0.008), and 3.2 ± 2.0 vs. 4.5 ± 1.7 (p = 0.006), respectively, based on the Pazirandeh et al. and Qiu et al. scoring systems. The percentage samples of high COX-2 expression score (4 to 5) in chronic hepatitis and cirrhosis were 16.3% vs. 45.8% (p = 0.022), and 23.3% vs. 50% (p = 0.021), respectively, based on the two scoring systems. The mean COX-2 expression scores based on the severity of hepatic fibrosis scored using Ishak's modified staging system (fibrosis score 0 to 3 vs. 4 to 6) were 2.4 ± 1.3 vs. 3.2 ± 1.1 (p = 0.009), and 3.1 ± 2.0 vs. 4.3 ± 1.8 (p = 0.009), respectively, based on the two scoring systems.
Conclusions
COX-2 expression was significantly higher in liver cirrhosis group than in chronic hepatitis. COX-2 expression scores according to Ishak's staging was significantly higher in the advanced fibrosis group. COX-2 may play a role in the progression of hepatic fibrosis.
- All Author(s)
- S. W. Jeong
; J. Y. Jang
; S. H. Lee
; S. G. Kim
; Y. K. Cheon
; Y. S. Kim
; Y. D. Cho
; H. S. Kim
; J. S. Lee
; S. Y. Jin
; C. S. Shim
; B. S. Kim
- Issued Date
- 2010
- Type
- Article
- Keyword
- Cyclooxygenase 2; Immunohistochemistry; Hepatitis, chronic; Liver cirrhosis
- Publisher
- 대한내과학회
Korean Association of Internal Medicine
- ISSN
- 1226-3303
; 2005-6648
- Citation Title
- The Korean journal of internal medicine
- Citation Volume
- 25
- Citation Number
- 4
- Citation Start Page
- 364
- Citation End Page
- 371
- Language(ISO)
- eng
- DOI
- 10.3904/kjim.2010.25.4.364
- URI
- http://schca-ir.schmc.ac.kr/handle/2022.oak/3248
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