Dosing study of esmolol for reducing hemodynamic changes during lightwand intubation
- Abstract
- Background: Lightwand is a convenient tool that can be used instead of a laryngoscope for intubation. Tracheal intubation causes direct stimulation of the larynx, drastically increasing hemodynamic values including blood pressure and heart rate. This study aims to identify the effect of different doses of esmolol on hemodynamic changes during lightwand intubation. Methods: The study subjects included 140 patients who underwent general anesthesia for elective surgery. The patients were randomly divided into four groups (35 patients in each group). The ‘C’ group only received 20 ml of normal saline, while the ‘E0.5’, ‘E1’, and ‘E2’ groups received 20 ml of normal saline containing esmolol—0.5 mg/kg, 1 mg/kg, and 2 mg/kg, respectively, injected 2 min prior to intubation. The patients’ blood pressure, heart rate, and rate-pressure product were measured six times, before and after the intubation.ResultsThe degree of heart rate elevation was suppressed in the E1 and E2 groups compared to the C group, and RPP after intubation significantly decreased in the E2 group compared to the C group. Conclusions: Esmolol injection, 1-2 mg/kg, prior to lightwand intubation effectively blunts heart rate elevation, and 2 mg/kg of esmolol injection blunts rate-pressure product elevation.
- All Author(s)
- J. K. Kang
; S. H. Yoo
; J. H. Chung
; N. S. Kim
; H. S. Jung
; Y. H. Seo
; H. R. Chun
; H. Y. Gong
; H. D. Son
; A. J. Kim
- Issued Date
- 2020
- Type
- Article
- Keyword
- Blood pressure; Esmolol; Heart rate; Intubation; Lightwand; Rate pressure product
- ISSN
- 1975-5171
; 2383-7977
- Citation Title
- Anesthesia and pain medicine
- Citation Volume
- 15
- Citation Number
- 4
- Citation Start Page
- 417
- Citation End Page
- 423
- Language(ISO)
- eng
- DOI
- 10.17085/apm.19067
- URI
- http://schca-ir.schmc.ac.kr//handle/2022.oak/328
- 공개 및 라이선스
-
- 파일 목록
-
Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.