Impact of obesity on the predictive accuracy of prostate-specific antigen density and prostate-specific antigen in native Korean men undergoing prostate biopsy
- Abstract
- OBJECTIVES: To evaluate the impact of obesity on the biopsy detection of prostate cancer. METHODS: We retrospectively reviewed data of 1182 consecutive Korean patients (≥50 years) with serum prostate-specific antigen levels of 3-10 ng/mL who underwent initial extended 12-cores biopsy from September 2009 to March 2013. Patients who took medications that were likely to influence the prostate-specific antigen level were excluded. Receiver operating characteristic curves were plotted for prostate-specific antigen and prostate-specific antigen density predicting cancer status among non-obese and obese men. RESULTS: A total of 1062 patients (mean age 67.1 years) were enrolled in the analysis. A total of 230 men (21.7%) had a positive biopsy. In the overall study sample, the area under the receiver operator characteristic curve of serum prostate-specific antigen for predicting prostate cancer on biopsy were 0.584 and 0.633 for non-obese and obese men, respectively (P = 0.234). However, the area under the curve for prostate-specific antigen density in predicting cancer status showed a significant difference (non-obese 0.696, obese 0.784; P = 0.017). CONCLUSIONS: There seems to be a significant difference in the ability of prostate-specific antigen density to predict biopsy results between non-obese and obese men. Obesity positively influenced the overall ability of prostate-specific antigen density to predict prostate cancer.
- All Author(s)
- J. H. Kim
; S. W. Doo
; W. J. Yang
; K. W. Lee
; C. H. Lee
; Y. S. Song
; Y. S. Jeon
; M. E. Kim
; S. S. Kwon
- Issued Date
- 2014
- Type
- Article
- Keyword
- Sternum; Metastasis}}Rencal cell carcinoma; Sternum reconstruction
- ISSN
- 0919-8172
- Citation Title
- International Journal of Surgery Case Reports
- Citation Volume
- 21
- Citation Number
- 10
- Citation Start Page
- 987
- Citation End Page
- 990
- Language(ISO)
- eng
- DOI
- 10.1111/iju.12486
- URI
- http://schca-ir.schmc.ac.kr/handle/2022.oak/3310
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