Effect of delayed hospitalization on patients with non-ST-segment elevation myocardial infarction and complex lesions undergoing successful new-generation drug-eluting stents implantation
- Abstract
- In the absence of available data, we evaluated the effects of delayed hospitalization (symptom-to-door time [SDT] ≥ 24 h) on major clinical outcomes after new-generation drug-eluting stent implantation in patients with non-ST-segment elevation myocardial infarction (NSTEMI) and complex lesions. In total, 4373 patients with NSTEMI were divided into complex (n = 2106) and non-complex (n = 2267) groups. The primary outcome was the 3-year rate of major adverse cardiac events (MACE), defined as all-cause death, recurrent MI, and any repeat revascularization. Secondary outcomes included the individual MACE components. In the complex group, all-cause death (adjusted hazard ratio [aHR], 1.752; p = 0.004) and cardiac death (aHR, 1.966; p = 0.010) rates were significantly higher for patients with SDT ≥ 24 h than for those with SDT < 24 h. In the non-complex group, all patients showed similar clinical outcomes. Patients with SDT < 24 h (aHR, 1.323; p = 0.031) and those with SDT ≥ 24 h (aHR, 1.606; p = 0.027) showed significantly higher rates of any repeat revascularization and all-cause death, respectively, in the complex group than in the non-complex group. Thus, in the complex group, delayed hospitalization was associated with higher 3-year mortalities.
- All Author(s)
- Yong Hoon Kim
; Ae-Young Her
; Seung-Woon Rha
; Cheol Ung Choi
; Byoung Geol Choi
; Ji Bak Kim
; Soohyung Park
; Dong Oh Kang
; Ji Young Park
; Woong Gil Choi
; Sang-Ho Park
; Myung Ho Jeong
- Issued Date
- 2023
- Type
- Article
- Publisher
- Nature Publishing Group
- ISSN
- 2045-2322
- Citation Title
- Scientific reports
- Citation Volume
- 13
- Citation Number
- 1
- Citation Start Page
- 16067
- Citation End Page
- 16067
- Language(ISO)
- eng
- DOI
- 10.1038/s41598-023-43385-3
- URI
- http://schca-ir.schmc.ac.kr/handle/2022.oak/3362
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