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The association of perfluoroalkyl substances (PFAS) exposure and kidney function in Korean adolescents using data from Korean National Environmental Health Survey (KoNEHS) cycle 4 (2018-2020): a cross-sectional study

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Abstract
Background: Perfluoroalkyl substances (PFAS) are chemicals widely used in various products in everyday life. Due to its unique strong binding force, the half-life of PFAS is very long, so bioaccumulation and toxicity to the human body are long-standing concerns. In particular, effects on kidney function have recently emerged and there are no studies on the effect of PFAS on kidney function through epidemiological investigations in Korea. From 2018 to 2020, the Korean National Environmental Health Survey (KoNEHS) cycle 4, conducted an epidemiological investigation on the blood concentration of PFAS for the first time in Korea. Based on this data, the relationship between PFAS blood concentration and kidney function was analyzed for adolescents.

Methods: We investigated 5 types of PFAS and their total blood concentration in 811 middle and high school students, living in Korea and included in KoNEHS cycle 4, and tried to find changes in kidney function in relation to PFAS concentration. After dividing the concentration of each of the 5 PFAS and the total concentration into quartiles, multivariable linear regression was performed to assess the correlation with kidney function. The bedside Schwartz equation was used as an indicator of kidney function.

Results: As a result of multivariable linear regression, when observing a change in kidney function according to the increase in the concentration of each of the 5 PFAS and their total, a significant decrease in kidney function was confirmed in some or all quartiles.

Conclusions: In this cross-sectional study of Korean adolescents based on KoNEHS data, a negative correlation between serum PFAS concentration and kidney function was found. A well-designed longitudinal study and continuous follow-up are necessary.
All Author(s)
Jisuk Yun ; Eun-Chul Jang ; Soon-Chan Kwon ; Young-Sun Min ; Yong-Jin Lee
Issued Date
2023
Type
Article
Keyword
Kidney functionKoNEHSPerfluoroalkyl substances (PFAS)
Publisher
대한직업환경의학회
The Korean Society of Occupational and Environmental Medicine
ISSN
2052-4374
Citation Title
Annals of occupational and environmental medicine
Citation Volume
35
Citation Number
1
Citation Start Page
e5
Citation End Page
e5
Language(ISO)
eng
DOI
10.35371/aoem.2023.35.e5
URI
http://schca-ir.schmc.ac.kr/handle/2022.oak/3413
Appears in Collections:
직업환경의학과 > 1. Journal Papers
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