Factors Associated With Achieving Complete Skin Clearance Compared to Almost Complete Skin Clearance in Patients With Moderate to Severe Psoriasis Treated With Biologics: A Retrospective Chart Review
- Abstract
- Background: Biologics have demonstrated high efficacy in achieving 'almost complete' skin clearance in patients with moderate to severe psoriasis. Nonetheless, achieving 'complete' skin clearance remains a treatment goal for some highly biologics-resistant patients, as residual lesions impact their quality of life.
Objective: The risk factors for failure to achieve a Psoriasis Area and Severity Index (PASI) 100 response in patients with good response to biologics remain unknown.
Methods: This retrospective study evaluated the risk factors by comparing patients who achieved complete skin clearance (PASI100) with those who achieved almost complete skin clearance (PASI90). A database of 131 psoriasis patients treated with biologics, who achieved a PASI90 or PASI100 response, was reviewed from a tertiary referral hospital in South Korea. The patients were classified into PASI90 and PASI100 groups according to their PASI response.
Results: The PASI100 group had a lower prevalence of smoking history (adjusted odds ratio [OR], 0.34; 95% confidence interval [CI], 0.14-0.85; p=0.021) and psoriasis on the anterior lower legs at baseline (adjusted OR, 0.18; 95% CI, 0.03-0.99; p=0.049) than patients in the PASI90 group.
Conclusion: This study suggested that smoking history and psoriatic skin lesions on the anterior lower legs are considered as the risk factors for the failure to achieve a PASI100 response in psoriasis patients treated with biologics.
- All Author(s)
- Eun Ji Hong
; Hee Jung Yoon
; Min Jung Kwon
; Jae Yun Kim
; Jung Eun Kim
; Young Lip Park
; SangHoon Lee
; Youin Bae
; Sul Hee Lee
- Issued Date
- 2024
- Type
- Article
- Keyword
- Biologics; Psoriasis; Risk factors
- Publisher
- 대한피부과학회
Korean Dermatological Association
- ISSN
- 1013-9087
; 2005-3894
- Citation Title
- Annals of dermatology
- Citation Volume
- 36
- Citation Number
- 2
- Citation Start Page
- 91
- Citation End Page
- 98
- Language(ISO)
- eng
- DOI
- 10.5021/ad.23.074
- URI
- http://schca-ir.schmc.ac.kr/handle/2022.oak/3426
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