Pathological phenotypes of astrocytes in Alzheimer's disease
- Abstract
- Astrocytes are involved in various processes in the central nervous system (CNS). As the most abundant cell type in the CNS, astrocytes play an essential role in neuronal maintenance and support, synaptic activity, neuronal metabolism, and amyloid-beta (Aβ) clearance. Alzheimer's disease (AD) is a neurodegenerative disorder associated with cognitive and behavioral impairment. The transformation of astrocytes is involved in various neurodegenerative diseases, such as AD. Since astrocytes have functional diversity and morphological and physiological heterogeneity in the CNS, AD-related astrocytes might show various pathological phenotypes during AD. Astrocytes developing pathological phenotypes could contribute to AD progression. In this review, we provide an overview of the pathological phenotypes of astrocytes in the context of AD, highlighting recent findings in human and mouse AD.
- All Author(s)
- Junhyung Kim
; Ik Dong Yoo
; Jaejoon Lim
; Jong-Seok Moon
- Issued Date
- 2024
- Type
- Article
- Publisher
- 생화학분자생물학회
Korean Society of Medical Biochemistry and Molecular Biology
- ISSN
- 1226-3613
; 2092-6413
- Citation Title
- Experimental & molecular medicine
- Citation Volume
- 56
- Citation Number
- 1
- Citation Start Page
- 95
- Citation End Page
- 99
- Language(ISO)
- eng
- DOI
- 10.1038/s12276-023-01148-0
- URI
- http://schca-ir.schmc.ac.kr/handle/2022.oak/3442
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