Effect of complicated, untreated and uncontrolled diabetes and pre-diabetes on treatment outcome among patients with pulmonary tuberculosis
- Abstract
- Background and objective: Patients with tuberculosis and diabetes have a higher risk of unfavourable anti-tuberculosis treatment outcomes. In the present study, we aimed to evaluate the effects of various diabetes statuses on the outcomes of patients with pulmonary tuberculosis.
Methods: Among the patients with pulmonary tuberculosis enrolled in the Korea Tuberculosis Cohort (KTBC) registry and the multicentre prospective cohort study of pulmonary tuberculosis (COSMOTB), those with diabetes and complicated diabetes were identified. The primary and secondary outcomes were unfavourable outcomes and mortality, respectively. The effect of diabetes and complicated diabetes on the outcomes was assessed using multivariable logistic regression analysis. Using COSMOTB, subgroup analyses were performed to assess the association between various diabetes statuses and outcomes.
Results: In the KTBC, diabetes (adjusted odds ratio [aOR] = 1.93, 95% CI = 1.64-2.26) and complicated diabetes (aOR = 1.96, 95% CI = 1.67-2.30) were significantly associated with unfavourable outcomes, consistent with the COSMOTB data analysis. Based on subgroup analysis, untreated diabetes at baseline was an independent risk factor for unfavourable outcomes (aOR = 2.72, 95% CI = 1.26-5.61). Prediabetes and uncontrolled diabetes increased unfavourable outcomes and mortality without statistical significance.
Conclusion: Untreated and complicated diabetes at the time of tuberculosis diagnosis increases the risk of unfavourable outcomes and mortality.
- All Author(s)
- Kyung Hoon Kim
; Hyung Woo Kim
; Yong Hyun Kim
; Yeonhee Park
; Sung Soo Jung
; Jin Woo Kim
; Jee Youn Oh
; Heayon Lee
; Sung Kyoung Kim
; Sun-Hyung Kim
; Jiwon Lyu
; Yousang Ko
; Sun Jung Kwon
; Yun-Jeong Jeong
; Do Jin Kim
; Hyeon-Kyoung Koo
; Yangjin Jegal
; Sun Young Kyung
; Sung Soon Lee
; Jae Seuk Park
; Ju Sang Kim
; Jinsoo Min
- Issued Date
- 2024
- Type
- Article
- Keyword
- diabetes mellitus; mortality; pre‐diabetes; treatment outcome; tuberculosis
- Publisher
- Asian Pacific Society of Respirology
- ISSN
- 1323-7799
; 1440-1843
- Citation Title
- Respirology
- Citation Volume
- 29
- Citation Number
- 7
- Citation Start Page
- 624
- Citation End Page
- 632
- Language(ISO)
- eng
- DOI
- 10.1111/resp.14714
- URI
- http://schca-ir.schmc.ac.kr/handle/2022.oak/3445
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