The Usefulness of (18)F-FDG PET to Differentiate Subtypes of Dementia: The Systematic Review and Meta-Analysis
- Abstract
- Background and purpose: Dementia subtypes, including Alzheimer's dementia (AD), dementia with Lewy bodies (DLB), and frontotemporal dementia (FTD), pose diagnostic challenges. This review examines the effectiveness of 18F-Fluorodeoxyglucose Positron Emission Tomography (18F-FDG PET) in differentiating these subtypes for precise treatment and management.
Methods: A systematic review following Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines was conducted using databases like PubMed and Embase to identify studies on the diagnostic utility of 18F-FDG PET in dementia. The search included studies up to November 16, 2022, focusing on peer-reviewed journals and applying the gold-standard clinical diagnosis for dementia subtypes.
Results: From 12,815 articles, 14 were selected for final analysis. For AD versus FTD, the sensitivity was 0.96 (95% confidence interval [CI], 0.88-0.98) and specificity was 0.84 (95% CI, 0.70-0.92). In the case of AD versus DLB, 18F-FDG PET showed a sensitivity of 0.93 (95% CI 0.88-0.98) and specificity of 0.92 (95% CI, 0.70-0.92). Lastly, when differentiating AD from non-AD dementias, the sensitivity was 0.86 (95% CI, 0.80-0.91) and the specificity was 0.88 (95% CI, 0.80-0.91). The studies mostly used case-control designs with visual and quantitative assessments.
Conclusions: 18F-FDG PET exhibits high sensitivity and specificity in differentiating dementia subtypes, particularly AD, FTD, and DLB. This method, while not a standalone diagnostic tool, significantly enhances diagnostic accuracy in uncertain cases, complementing clinical assessments and structural imaging.
- All Author(s)
- Seunghee Na
; Dong Woo Kang
; Geon Ha Kim
; Ko Woon Kim
; Yeshin Kim
; Hee-Jin Kim
; Kee Hyung Park
; Young Ho Park
; Gihwan Byeon
; Jeewon Suh
; Joon Hyun Shin
; YongSoo Shim
; YoungSoon Yang
; Yoo Hyun Um
; Seong-Il Oh
; Sheng-Min Wang
; Bora Yoon
; Hai-Jeon Yoon
; Sun Min Lee
; Juyoun Lee
; Jin San Lee
; Hak Young Rhee
; Jae-Sung Lim
; Young Hee Jung
; Juhee Chin
; Yun Jeong Hong
; Hyemin Jang
; Hongyoon Choi
; Miyoung Choi
; Jae-Won Jang
; Korean Dementia Association
- Issued Date
- 2024
- Type
- Article
- Keyword
- Alzheimer’s Disease; Dementia; Fluorodeoxyglucose F18; Frontotemporal Dementia; Lewy Body Disease; Meta-Analysis; Positron Emission Tomography Computed Tomography
- Publisher
- 대한치매학회
Korean Dementia Association
- ISSN
- 1738-1495
; 2384-0757
- Citation Title
- Dementia and neurocognitive disorders
- Citation Volume
- 23
- Citation Number
- 1
- Citation Start Page
- 54
- Citation End Page
- 66
- Language(ISO)
- eng
- DOI
- 10.12779/dnd.2024.23.1.54
- URI
- http://schca-ir.schmc.ac.kr/handle/2022.oak/3463
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