비편평세포, 비소세포폐암 환자에서 erlotinib, gefitinib 및 pemetrexed의 효과

Abstract

Background/Aims: This study compared the clinical benefits of epidermal growth factor receptor tyrosine kinase inhibitors(EGFR TKIs) with pemetrexed to identify the clinical parameters that correlated with response. Methods: A retrospective chart review examined patients who were 1) treated with EGFR TKI or pemetrexed, 2) diagnosed withadvanced non-squamous non-small-cell lung cancer, and 3) previously treated with platinum-based chemotherapy in SoonchunhyangBucheon Hospital. Results: Sixty-one patients (18 erlotinib, 18 gefitinib, 25 pemetrexed) were investigated from February 2002 to August 2009.The median follow-up period was 37 months (7~97 months). Overall, their median age was 63 years, 41 patients were non-smokers,57 patients had adenocarcinoma, and 55 patients were at stage IV. Twenty-one patients received the study drugs as second-line chemotherapy,and others as third-line or more. No significant differences in the overall response rate (erlotinib 33.3% vs. gefitinib38.9% vs. pemetrexed 20.0%) and progression-free survival (erlotinib 1.9 months vs. gefitinib 3.0 months vs. pemetrexed 2.9months) were found among the three groups. Female gender was related to a good response to EGFR TKIs (p=0.047). Skin rash inthe erlotinib group (p=0.037) and adenocarcinoma in the pemetrexed group (p=0.02) were related to improved progression-freesurvival. Few side effects were reported. Conclusions: Both EGFR TKIs and pemetrexed therapy for non-squamous non-small-cell lung cancer were efficient and tolerableafter the failure of first-line platinum-based chemotherapy. Further prospective studies are needed to validate the predictiverole of the suggested clinical parameters in this study. (Korean J Med 79:394-403, 2010)