산조인이 백서 뇌에 미치는 영향 - 세로토닌, 수면시간, 수면뇌파, 자동운동을 중심으로
- Alternative Title
- Effects of the Sanjoin on the Rat Brain - Focused on Serotonin, Sleeping Time, Sleep EEG and Autonomic Activity -
- Abstract
- Objects : Sanjoin, the seeds of Zizyphus vulgaris var. spinosus has been used as the most important hypnotic agent in chinese medicine to treat insomnia. This research was performed in order to examine the effect of betulinic acid and sanjoinine-A which are components of Sanjoin. Method : Sleeping time, sleep recordings of EEG, EMG, serum serotonin level, and locomotor activity were measured in rats which received betulinic acid and sanjoinine-A as sleep induction material extracted from Sanjoin. Results : 1) Groups received betulinic acid, sanjoinine-A, and lorazepam showed increased sleep time than control group with saline. 2) Groups with betulinic acid, sanjoinine-A, lorazepam and saline recorded ${\beta}$-wave in sleep recordings of EEG. In EMG, there was no significant difference among all groups. 3) No significant difference in serum serotonin level among all groups was found. 4) In autonomic activity testing, groups of betulinic acid, sanjoinine-A, and lorazepam showed significantly more decreased in activity than saline group. In comparison of groups of betulinic acid and sanjoinine-A with a group of lorazepam, there was no significant difference. Conclusion : These results suggest that betulinic acid and sanjoinine-A have the sedative effect like lorazepam rather than sleep effect.
- All Author(s)
- 정희연
; 권영준
; 박인준
; 권준택
; 한병훈
; 이성필
- Issued Date
- 1997
- Type
- Article
- Keyword
- Sanjoin; Sanjoinine-A; Betulinic acid; Serotonin; Sedative effect
- Publisher
- 대한생물정신의학회
- ISSN
- 1225-8709
; 2005-7571
- Citation Title
- 생물정신의학
Korean Journal of Biological Psychiatry
- Citation Volume
- 4
- Citation Number
- 1
- Citation Start Page
- 54
- Citation End Page
- 59
- Language(ISO)
- kor
- URI
- http://schca-ir.schmc.ac.kr/handle/2022.oak/463
- 공개 및 라이선스
-
- 파일 목록
-
Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.