Accelerated partial breast irradiation using multicatheter brachytherapy for select early-stage breast cancer: local control and toxicity
- Abstract
- BACKGROUND: To investigate the efficacy and safety of accelerated partial breast irradiation (APBI) via high-dose-rate (HDR) multicatheter interstitial brachytherapy for early-stage breast cancer. METHODS: Between 2002 and 2006, 48 prospectively selected patients with early-stage breast cancer received APBI using multicatheter brachytherapy following breast-conserving surgery. Their median age was 52 years (range 36-78). A median of 34 Gy (range 30-34) in 10 fractions given twice daily within 5 days was delivered to the tumor bed plus a 1-2 cm margin. Most (92%) patients received adjuvant systemic treatments. The median follow-up was 53 months (range 36-95). Actuarial local control rate was estimated from surgery using Kaplan-Meier method. RESULTS: Local recurrence occurred in two patients. Both were true recurrence/marginal miss and developed in patients with close (< 0.2 cm) surgical margin after 33 and 40 months. The 5-year actuarial local recurrence rate was 4.6%. No regional or distant relapse and death has occurred to date. Late Grade 1 or 2 late skin and subcutaneous toxicity was seen in 11 (22.9%) and 26 (54.2%) patients, respectively. The volumes receiving 100% and 150% of the prescribed dose were significantly higher in the patients with late subcutaneous toxicity (p = 0.018 and 0.034, respectively). Cosmesis was excellent to good in 89.6%. CONCLUSIONS: APBI using HDR multicatheter brachytherapy yielded local control, toxicity, and cosmesis comparable to those of conventional whole breast irradiation for select early-stage breast cancer. Patients with close resection margins may be ineligible for APBI.
- All Author(s)
- S. G. Yeo
; J. Kim
; G. H. Kwak
; J. Y. Kim
; K. Park
; E. S. Kim
; S. Han
- Issued Date
- 2010
- Type
- Article
- Keyword
- Brachytherapy/adverse effects/*methods; Breast Neoplasms/*radiotherapy/surgery; Catheterization; Combined Modality Therapy; Female; Humans; Kaplan-Meier Estimate; Mastectomy, Segmental; Middle Aged; Neoplasm Recurrence, Local/epidemiology; Radiotherapy, Adjuvant/adverse effects/methods; Treatment Outcome
- ISSN
- 1748-717x
- Citation Title
- Radiation Oncology
- Citation Volume
- 5
- Citation Start Page
- 56
- Citation End Page
- 56
- Language(ISO)
- eng
- DOI
- 10.1186/1748-717x-5-56
- URI
- http://schca-ir.schmc.ac.kr/handle/2022.oak/625
- 공개 및 라이선스
-
- 파일 목록
-
Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.