Air trapping is a major determinant of persistent airway obstruction in asthmatics
- Abstract
- Chronic persistent airway obstruction has been observed in moderate-to-severe asthmatics despite treatment with inhaled corticosteroids. We investigated which airway changes were associated with this obstruction. High-resolution computed tomography (HRCT) was performed at study entry and reexamined at the time of follow-up when the FEV1 reached a maximally constant level after treatment for 1 year or more with inhaled corticosteroids. Bronchial wall area and air trapping extent were compared in the recovered group (n = 18) and the persistent airway obstruction group (n = 14). Bronchial wall area and air trapping of the initial HRCT were similar between the two groups. On follow-up HRCT, air trapping was markedly decreased in the recovered group compared with that on initial HRCT (P = 0.017), whereas bronchial wall area did not change. In the persistent-airway-obstruction group, these two parameters did not change during follow-up. When follow-up HRCT was compared, air trapping was significantly greater in the persistent-airway-obstruction group than in the recovered group (P = 0.003). Difference post-bronchodilator FEV1 value between at initial and 2nd HRCT exam was correlated with difference air trapping value between at initial and 2nd HRCT exam(%) on the follow-up HRCT (P = 0.017). The presence of persistent airflow obstruction were significantly associated with the air trapping % difference between initial and 2nd time (RR = 1.70, P = 0.018). Persistence of AT could be a main contributing factor to chronic persistent airflow obstruction in asthma. (C) 2012 Elsevier Ltd. All rights reserved.
- All Author(s)
- S. W. Park
; J. S. Park
; S. H. Jeong
; Y. N. Lee
; Y. Hwangbo
; J. H. Lee
; A. S. Jang
; D. J. Kim
; S. T. Uh
; Y. H. Kim
; C. S. Park
- Issued Date
- 2012
- Type
- Article
- Keyword
- Asthma; Airway obstruction; Persistence; Air trapping; Lung CT; Inhaled
corticosteroid
- ISSN
- 0954-6111
- Citation Title
- Respiratory Medicine
- Citation Volume
- 106
- Citation Number
- 6
- Citation Start Page
- 786
- Citation End Page
- 793
- Language(ISO)
- eng
- DOI
- 10.1016/j.rmed.2012.02.012
- URI
- http://schca-ir.schmc.ac.kr/handle/2022.oak/693
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