Helicobacter pylori 감염진단을 위한 38 mg 저용량 13C-요소호기 검사의 타당도
- Alternative Title
- Validity of 38 mg Low Dose 13C-Urea Breath Test for the Diagnosis of Helicobacter pylori Infection
- Abstract
- Background: To assess the diagnostic value of 13C-UBT using capsulated 38 mg low dose for H. pylori infection, we investigated the sensitivity and specificity of 13C-UBT and to suggest the optimal positive cut-off value of DOB20 in 13C-UBT using ROC analysis. Methods: The study subjects were 76 healthy individuals (males; 52, females; 24) who visited a health promotion center at a university hospital between July 2005 and June 2007. We tested for H. pylori infection by 38 mg low dose 13C-UBT and histology. We measured the expiratory 13C- urea concentration of basal and 20 minutes value after oral ingestion of 38 mg 13C- labelled urea with capsulated. The breath samples were analysed by gas chromatograph isotope ratio mass spectrometer and expressed as units of delta. Results: Fifty subjects (65.8%) were H. pylori positive as judged from histology. ROC analysis showed an area under the curve (AUC) of 0.943 (95% confidence interval: 0.891∼0.995), indicating an excellent classification performance of the model. The sensitivity of 96%, specificity of 85% were achieved at the optimal cut-off value of DOB20 which was 1.39. The 38 mg low dose 13C-UBT was a non-invasive, simple, short-time required and highly accurate method. Conclusion: The results suggested that capsulated 38 mg low dose 13C-UBT is considered more in term of accuracy, costeffectiveness and convenient method for the diagnosis of H. pylori infection. Further long-term research and meta analysis based on large-scale investigations is needed to establish a standardized testing method in creating protocol of 13C-UBT.
- All Author(s)
- Y. J. Lee
; E. C. Jang
; Y. J. Cho
; J. E. Oh
; Y. B. Kim
; H. S. Nam
- Issued Date
- 2008
- Type
- Article
- Keyword
- H. pylori infection; 38 mg low dose 13C-urea breath test; validity
- Publisher
- 대한가정의학회
- ISSN
- 1225-4908
- Citation Title
- 가정의학회지
journal of the Korean Academy of Family Medicine
- Citation Volume
- 29
- Citation Number
- 10
- Citation Start Page
- 788
- Citation End Page
- 794
- Language(ISO)
- kor
- URI
- http://schca-ir.schmc.ac.kr/handle/2022.oak/750
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