Association Analysis Between FILIP1 Polymorphisms and Aspirin Hypersensitivity in Korean Asthmatics
- Abstract
- Purpose: Aspirin exacerbated respiratory disease (AERD) results in a severe asthma attack after aspirin ingestion in asthmatics. The filamin A interacting protein 1 (FILIP1) may play a crucial role in AERD pathogenesis by mediating T cell activation and membrane rearrangement. We investigated the association of FILIP1 variations with AERD and the fall rate of forced expiratory volume in one second (FEV1). Methods: A total of 34 common FILIP1 single nucleotide polymorphisms (SNPs) were genotyped in 592 Korean asthmatic subjects that included 163 AERD patients and 429 aspirin-tolerant asthma (ATA) controls. Results: This study found that 5 SNPs (P=0.006-0.01) and 2 haplotypes (P=0.01-0.03) of FILIP1 showed nominal signals; however, corrections for the multiple testing revealed no significant associations with the development of AERD (P-corr>0.05). In addition, association analysis of the genetic variants with the fall rate of FEV1, an important diagnostic marker of AERD, revealed no significant evidence (P-corr>0.05). Conclusions: Although further replications and functional evaluations are needed, our preliminary findings suggest that genetic variant of FILIP1 might be not associated with the onset of AERD.
- All Author(s)
- J. Y. Kim
; J. H. Kim
; B. L. Park
; C. F. A. Pasaje
; J. S. Bae
; S. Park
; A. S. Jang
; S. T. Uh
; Y. H. Kim
; M. K. Kim
; I. S. Choi
; S. H. Cho
; B. W. Choi
; C. S. Park
; H. D. Shin
- Issued Date
- 2013
- Type
- Article
- Keyword
- Filamin A interacting protein 1; single nucleotide polymorphism; haplotype; asthma; aspirin exacerbated respiratory disease
- ISSN
- 2092-7355
- Citation Title
- Allergy Asthma & Immunology Research
- Citation Volume
- 5
- Citation Number
- 1
- Citation Start Page
- 34
- Citation End Page
- 41
- Language(ISO)
- eng
- DOI
- 10.4168/aair.2013.5.1.34
- URI
- http://schca-ir.schmc.ac.kr/handle/2022.oak/848
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