신우신염 환아의 1회 배설뇨에서 β2-microglobulin 측정의 유용성
- Alternative Title
- Usefulness of Spot Urine β2-microglobulin in Pediatric Acute Pyelonephritis
- Abstract
- Objective:
It is difficult to make a distinction between acute pyelonephritis and lower urinary tract infection due to nonspecific clinical symptoms and laboratory findings. We measured the spot urine β2-microglobulin in children with urinary tract infection (UTI) to distinguish between acute pyelonephritis and lower UTI. We compared the accuracy of urine β2-microglobulin measurement with other inflammatory markers.
Methods:
We studied 83 children (mean, 86±44.9 months) who suspected of having UTI. Leukocyte counts, erythrocyte sedimentation rates (ESR) and C-reactive protein (CRP), β2-microglobulin were measured. Renal parenchymal involvement was evaluated by 99mTc dimercaptosuccinic acid scintigraphy in the first 7 days after admission. β2-microglobulin was measured by radioimmunoassay.
Results:
Urine β2-microglobulin values were correlated with the presence of renal defects in children with UTI (n= 22) (0.98± 0.24 μg/mL, P < 0.05). Using a cutoff of 0.4 μg/mL for spot urine β2-microglobulin and 20 mm/hr for ESR, 2.6 mg/L for CRP, sensitivity and specificity between UTI with and without renal involvement were 78.7% and 90.1% for spot urine β2-microglobulin, 77.2% and 90.1% for spot urine β2-microglobulin/creatinine (Cr), 77.2%, 68.8% for ESR, 86.3%, 68.8% for CRP, respectively. Positive and negative predictive values were 72.7%, 90.1% for spot urine β2-microglobulin, 73.9% and 91.6% for spot urine β2-microglobulin/Cr, and 57.5%, 94% for CRP, respectively.
Conclusion:
In febrile UTI, spot urine β2-microglobulin and β2-microglobulin/Cr values were more specific than CRP, ESR, and leukocyte count for determine the renal defects.
- All Author(s)
- H. S. Oh
; S. P. Bae
; S. S. Kim
; K. B. Park
- Issued Date
- 2012
- Type
- Article
- Keyword
- Beta 2-microglobulin; Urinary tract infections; Acute pyelonephritis; Pediatrics
- Publisher
- Soonchunhyang Medical Research Institute
- ISSN
- 2233-4289
- Citation Title
- Soonchunhyang Medical Science
- Citation Volume
- 18
- Citation Number
- 2
- Citation Start Page
- 91
- Citation End Page
- 94
- Language(ISO)
- kor
- DOI
- 10.15746/sms.12.018
- URI
- http://schca-ir.schmc.ac.kr/handle/2022.oak/881
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