Angiotensin converting enzyme inhibitors versus angiotensin II type 1 receptor blockers in patients with acute myocardial infarction and prediabetes after successful implantation of newer-generation drug-eluting stents
- Abstract
- BACKGROUND: Because limited data are available, the present study investigated 2-year major clinical outcomes after angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II type 1 receptor blockers (ARBs) therapy in patients with acute myocardial infarction (AMI) and prediabetes after successful implantation of newer-generation drug-eluting stents (DESs). METHODS: Overall, 2932 patients with AMI and prediabetes were classified into two groups - the ACEIs group (n = 2059) and the ARBs group (n = 873). The primary endpoint was the occurrence of patient-oriented composite outcome (POCO), defined as all-cause death, recurrent myocardial infarction (Re-MI), or any repeat revascularization. The secondary endpoint was definite or probable stent thrombosis (ST). RESULTS: The cumulative incidences of POCO (adjusted hazard ratio [aHR]: 1.020; 95% confidence interval [CI]: 0.740-1.404; p = 0.906), all-cause death (aHR: 1.394; 95% CI: 0.803-2.419; p = 0.238), Re-MI (aHR: 1.210; 95% CI: 0.626-2.340; p = 0.570), any repeat revascularization (aHR: 1.150; 95% CI: 0.713-1.855; p = 0.568), and ST (aHR: 1.736; 95% CI: 0.445-6.766; p = 0.427) were similar between the groups. These results were confirmed after propensity score-adjusted analysis. CONCLUSIONS: In this study, patients with AMI and prediabetes who received ACEIs or ARBs showed comparable clinical outcomes during the 2-year follow-up period.
- All Author(s)
- Y. H. Kim
; A. Y. Her
; M. H. Jeong
; B. K. Kim
; S. J. Hong
; S. H. Park
; S. Kim
; C. M. Ahn
; J. S. Kim
; Y. G. Ko
; D. Choi
; M. K. Hong
; Y. Jang
- Issued Date
- 2021
- Type
- Article
- Keyword
- angiotensin-converting enzyme inhibitor; angiotensin receptor blocker; myocardial infarction; prediabetes; outcomes
- ISSN
- 1898-018x
- Citation Title
- Cardiology Journal
- Language(ISO)
- eng
- DOI
- 10.5603/CJ.a2021.0116
- URI
- http://schca-ir.schmc.ac.kr/handle/2022.oak/899
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